UTILIZING POLYETHYLENE GLYCOL TO IMPROVE THE SOLUBILITY AND DISSOLUTION RATE OF CLARITHROMYCIN BY THE SOLID DISPERSION METHOD

Abstract

Clarithromycin (CAL), a poorly water-soluble agent, is a novel broad-spectrum macrolide antibiotic utilised in various infections. The current study aimed to enhance its solubility and dissolution rate by formulating solid dispersions with different polyethylene glycols (PEG). These solid dispersions were synthesised via the solvent evaporation technique at varying drug-to-PEG 4000 and 6000 ratios. The dissolving investigation of the prepared solid dispersions revealed that the value of the greatest cumulative release of the solid dispersion formula clarithromycin-PEG4000 ratio (1:1) (CALPEG4000) (1.1) was 99.49%; nevertheless, the dissolution efficacy (DE) was rich at a significant level (88.4) with a ratio (1:9). The Fourier transform infrared spectroscopy (FTIR) spectra revealed that there was no interaction between the medication and PEG when physically combined, indicating that the formulation's components are highly compatible Pure CAL has a melting point of 228. In contrast, when combined with polymers PEG4000 and 6000, the melting point drops to around 214 and 219, respectively, according to the differential scanning calorimetry (DSC) test. Finally, the use of hydrophilic carriers, such as PEG, dramatically improved the dissolution rate and solubility of CAL.